Just thought i'd take a few minutes to properly write a quick review on this, since I was going to ages ago and never got the chance.
I've used this ROM Cleaner both in it's earlier testing phase and with the latest version. I've found it very easy to setup and flash in both instances. It's worked at greatly reducing the clutter in roms and also helped reduce the amount of time spent having to do tasks such as reinstall apps after flashing a new rom from clean. I've so far tried it on Android Revolution HD, and it did everything i thought it would, from cleaning out the un-needed HTC junk to reinstalling all my apps!
The user file is very easy to maintain and edit as needed and will keep all the bits you want to keep and get rid of the rest.
So far i've experience no issues after removing 90% of the default list and have found that memory and the responsiveness of the Sensation to have improved.
I can only see this script/mod go from strength to strength and suggest that you try it out and see how it works for you.
You can download the latest version of ROM Cleaner from it's XDA thread on XDA Developers. You will need to flash it from CWM.